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Nicholas Peraino, Ph.D. |
| Title |
Senior Research Scientist |
| Location |
Mass Spectrometry Core Facility
Lumigen Instrumentation Center
A. Paul Schaap Chemistry Building
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| Education |
B.S. Chemical Engineering, Western Michigan University, 2009
Ph.D. Biomedical Sciences, Oakland University, 2017
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| Office |
Chem 043 |
| Phone |
(313) 577-2564 |
| E-Mail |
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Dr. Peraino received his B.S. in Chemical Engineering from Western Michigan University and Ph.D. in Biomedical Sciences from Oakland University. He brings experience in process modeling, programming, process control, fluid dynamics, mass/energy transfer, data analysis, reaction kinetics, organic synthesis, analytical, and computational chemistry. His instrumentation focuses are GC/MS, LC/MS, MALDI-IMS, IR, EDX, and Polarimetry. Major project classes include: 1) optimization and modeling of the manufacture of large scale chemical process material; 2) optimization, synthesis, and modeling of small scale specialty organic compounds; 3) reaction modeling and kinetics using Gaussian and enzyme interactions using AutoDock; 4) analysis and quantitation of metabolites and toxins in biological, food, and environmental matrixes; 5) excipient alterations due to novel preparative technique; 6) natural product discovery and characterization; 7) histopathological exposomics by MALDI-IMS; 8) protein and protein conjugate identification and characterization; 9) quantitation of enzyme mutation, and 10) targeted metabolomic profiling.
REPRESENTATIVE PUBLICATIONS
A complete list available at:
https://scholar.google.com/citations?user=qZJf600AAAAJ&hl=en
Catalytic Nitrene Homocoupling by an Iron(II) Bis(alkoxide) Complex: Bulking Up the Alkoxide Enables a Wider Range of Substrates and Provides Insight into the Reaction Mechanism
Maryam Yousif, Duleeka Wannipurage, Caleb D. Huizenga, Elizabeth Washnock-Schmid, Nicholas J. Peraino, Andrew Ozarowski, Sebastian A. Stoian, Richard L. Lord, and Stanislav Groysman
Inorganic Chemistry 2018 57 (15), 9425-9438
DOI: 10.1021/acs.inorgchem.8b01418
Asymmetric Synthesis of Lactones through Koga Amine-Controlled Addition of Enediolates to Alpha-Unsaturated Sulfoxonium Salts
Nicholas J. Peraino, Sven H. Kaster, Kraig A. Wheeler, and Nessan J. Kerrigan
The Journal of Organic Chemistry 2017 82 (1), 606-615
DOI: 10.1021/acs.joc.6b02622
Catalytic Asymmetric Synthesis of Ketene Heterodimer Gamma-Lactones: Scope and Limitations
Shi Chen, Ahmad A. Ibrahim, Nicholas J. Peraino, Divya Nalla, Mukulesh Mondal,Maxwell Van Raaphorst,vand Nessan J. Kerrigan
The Journal of Organic Chemistry 2016 81 (17),b7824-7837
DOI: 10.1021/acs.joc.6b01481
Asymmetric synthesis of gamma-lactones through reaction of sulfoxonium ylides, aldehydes, and ketenes
Nicholas J. Peraino, Han-Jen Ho, Mukulesh Mondal, Nessan J. Kerrigan,
Tetrahedron Letters, 2014 55 (30), 4260-4263 DOI: 10.1016/j.tetlet.2014.05.130.
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