Wayne State University

College of Liberal Arts & Sciences
Lumigen Instrument Center
Mass Spectrometry Profile
Nicholas Peraino, Ph.D.
Title Senior Research Scientist
Location Mass Spectrometry Core Facility
Lumigen Instrumentation Center
A. Paul Schaap Chemistry Building
Education B.S. Chemical Engineering, Western Michigan University, 2009
Ph.D. Biomedical Sciences, Oakland University, 2017
Office Chem 043
Phone (313) 577-2564

Dr. Peraino received his B.S. in Chemical Engineering from Western Michigan University and Ph.D. in Biomedical Sciences from Oakland University. He brings experience in process modeling, programming, process control, fluid dynamics, mass/energy transfer, data analysis, reaction kinetics, organic synthesis, analytical, and computational chemistry. His instrumentation focuses are GC/MS, LC/MS, MALDI-IMS, IR, EDX, and Polarimetry. Major project classes include: 1) optimization and modeling of the manufacture of large scale chemical process material; 2) optimization, synthesis, and modeling of small scale specialty organic compounds; 3) reaction modeling and kinetics using Gaussian and enzyme interactions using AutoDock; 4) analysis and quantitation of metabolites and toxins in biological, food, and environmental matrixes; 5) excipient alterations due to novel preparative technique; 6) natural product discovery and characterization; 7) histopathological exposomics by MALDI-IMS; 8) protein and protein conjugate identification and characterization; 9) quantitation of enzyme mutation, and 10) targeted metabolomic profiling.


A complete list available at: https://scholar.google.com/citations?user=qZJf600AAAAJ&hl=en

Catalytic Nitrene Homocoupling by an Iron(II) Bis(alkoxide) Complex: Bulking Up the Alkoxide Enables a Wider Range of Substrates and Provides Insight into the Reaction Mechanism Maryam Yousif, Duleeka Wannipurage, Caleb D. Huizenga, Elizabeth Washnock-Schmid, Nicholas J. Peraino, Andrew Ozarowski, Sebastian A. Stoian, Richard L. Lord, and Stanislav Groysman Inorganic Chemistry 2018 57 (15), 9425-9438 DOI: 10.1021/acs.inorgchem.8b01418

Asymmetric Synthesis of Lactones through Koga Amine-Controlled Addition of Enediolates to Alpha-Unsaturated Sulfoxonium Salts Nicholas J. Peraino, Sven H. Kaster, Kraig A. Wheeler, and Nessan J. Kerrigan The Journal of Organic Chemistry 2017 82 (1), 606-615 DOI: 10.1021/acs.joc.6b02622

Catalytic Asymmetric Synthesis of Ketene Heterodimer Gamma-Lactones: Scope and Limitations Shi Chen, Ahmad A. Ibrahim, Nicholas J. Peraino, Divya Nalla, Mukulesh Mondal,Maxwell Van Raaphorst,vand Nessan J. Kerrigan The Journal of Organic Chemistry 2016 81 (17),b7824-7837 DOI: 10.1021/acs.joc.6b01481

Asymmetric synthesis of gamma-lactones through reaction of sulfoxonium ylides, aldehydes, and ketenes Nicholas J. Peraino, Han-Jen Ho, Mukulesh Mondal, Nessan J. Kerrigan, Tetrahedron Letters, 2014 55 (30), 4260-4263 DOI: 10.1016/j.tetlet.2014.05.130.

5101 Cass Ave, Detroit, MI 48202

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